diff --git a/examples/Cargo.toml b/examples/Cargo.toml
index 6a61e10..e9c9662 100644
--- a/examples/Cargo.toml
+++ b/examples/Cargo.toml
@@ -181,7 +181,7 @@ path = "src/streaming/server.rs"
 [dependencies]
 async-stream = "0.3"
 futures = { version = "0.3", default-features = false, features = ["alloc"] }
-prost = "0.9"
+prost = "0.10"
 tokio = { version = "1.0", features = [ "rt-multi-thread", "time", "fs", "macros", "net",] }
 tokio-stream = { version = "0.1", features = ["net"] }
 tonic = { path = "../tonic", features = ["tls", "compression"] }
@@ -196,7 +196,7 @@ tracing-attributes = "0.1"
 tracing-futures = "0.2"
 tracing-subscriber = { version = "0.3", features = ["tracing-log"] }
 # Required for wellknown types
-prost-types = "0.9"
+prost-types = "0.10"
 # Hyper example
 http = "0.2"
 http-body = "0.4.2"
diff --git a/interop/Cargo.toml b/interop/Cargo.toml
index 5922f51..dc18d6f 100644
--- a/interop/Cargo.toml
+++ b/interop/Cargo.toml
@@ -24,8 +24,8 @@ futures-util = "0.3"
 http = "0.2"
 http-body = "0.4.2"
 hyper = "0.14"
-prost = "0.9"
-prost-derive = "0.9"
+prost = "0.10"
+prost-derive = "0.10"
 tokio = {version = "1.0", features = ["rt-multi-thread", "time", "macros", "fs"]}
 tokio-stream = "0.1"
 tonic = {path = "../tonic", features = ["tls"]}
diff --git a/tests/ambiguous_methods/Cargo.toml b/tests/ambiguous_methods/Cargo.toml
index b009546..e37e00c 100644
--- a/tests/ambiguous_methods/Cargo.toml
+++ b/tests/ambiguous_methods/Cargo.toml
@@ -9,7 +9,7 @@ version = "0.1.0"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-prost = "0.9"
+prost = "0.10"
 tonic = {path = "../../tonic"}
 
 [build-dependencies]
diff --git a/tests/compression/Cargo.toml b/tests/compression/Cargo.toml
index a9a0df1..5a59f56 100644
--- a/tests/compression/Cargo.toml
+++ b/tests/compression/Cargo.toml
@@ -13,7 +13,7 @@ http = "0.2"
 http-body = "0.4"
 hyper = "0.14.3"
 pin-project = "1.0"
-prost = "0.9"
+prost = "0.10"
 tokio = {version = "1.0", features = ["macros", "rt-multi-thread", "net"]}
 tokio-stream = {version = "0.1.5", features = ["net"]}
 tonic = {path = "../../tonic", features = ["compression"]}
diff --git a/tests/extern_path/my_application/Cargo.toml b/tests/extern_path/my_application/Cargo.toml
index e16c0f2..c4e8249 100644
--- a/tests/extern_path/my_application/Cargo.toml
+++ b/tests/extern_path/my_application/Cargo.toml
@@ -9,8 +9,8 @@ version = "0.1.0"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-prost = "0.9"
-prost-types = "0.9"
+prost = "0.10"
+prost-types = "0.10"
 tonic = {path = "../../../tonic"}
 uuid = {package = "uuid1", path = "../uuid"}
 
diff --git a/tests/extern_path/uuid/Cargo.toml b/tests/extern_path/uuid/Cargo.toml
index 450aa74..72c2fee 100644
--- a/tests/extern_path/uuid/Cargo.toml
+++ b/tests/extern_path/uuid/Cargo.toml
@@ -10,6 +10,6 @@ version = "0.1.0"
 
 [dependencies]
 bytes = "1.0"
-prost = "0.9"
+prost = "0.10"
 [build-dependencies]
-prost-build = "0.9"
+prost-build = "0.10"
diff --git a/tests/included_service/Cargo.toml b/tests/included_service/Cargo.toml
index 6b4ce19..b774779 100644
--- a/tests/included_service/Cargo.toml
+++ b/tests/included_service/Cargo.toml
@@ -9,7 +9,7 @@ version = "0.1.0"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-prost = "0.9"
+prost = "0.10"
 tonic = {path = "../../tonic"}
 
 [build-dependencies]
diff --git a/tests/integration_tests/Cargo.toml b/tests/integration_tests/Cargo.toml
index 1382649..289054b 100644
--- a/tests/integration_tests/Cargo.toml
+++ b/tests/integration_tests/Cargo.toml
@@ -11,7 +11,7 @@ version = "0.1.0"
 [dependencies]
 bytes = "1.0"
 futures-util = "0.3"
-prost = "0.9"
+prost = "0.10"
 tokio = {version = "1.0", features = ["macros", "rt-multi-thread", "net"]}
 tonic = {path = "../../tonic"}
 
diff --git a/tests/root-crate-path/Cargo.toml b/tests/root-crate-path/Cargo.toml
index 852169b..1a20afb 100644
--- a/tests/root-crate-path/Cargo.toml
+++ b/tests/root-crate-path/Cargo.toml
@@ -7,7 +7,7 @@ publish = false
 version = "0.1.0"
 
 [dependencies]
-prost = "0.9"
+prost = "0.10"
 tonic = {path = "../../tonic"}
 
 [build_dependencies]
diff --git a/tests/same_name/Cargo.toml b/tests/same_name/Cargo.toml
index 5640842..8b5579b 100644
--- a/tests/same_name/Cargo.toml
+++ b/tests/same_name/Cargo.toml
@@ -9,7 +9,7 @@ version = "0.1.0"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-prost = "0.9"
+prost = "0.10"
 tonic = {path = "../../tonic"}
 
 [build-dependencies]
diff --git a/tests/service_named_service/Cargo.toml b/tests/service_named_service/Cargo.toml
index 3eb6178..263da26 100644
--- a/tests/service_named_service/Cargo.toml
+++ b/tests/service_named_service/Cargo.toml
@@ -9,7 +9,7 @@ version = "0.1.0"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-prost = "0.9"
+prost = "0.10"
 tonic = {path = "../../tonic"}
 
 [build-dependencies]
diff --git a/tests/stream_conflict/Cargo.toml b/tests/stream_conflict/Cargo.toml
index d5bce32..facf1c2 100644
--- a/tests/stream_conflict/Cargo.toml
+++ b/tests/stream_conflict/Cargo.toml
@@ -9,7 +9,7 @@ license = "MIT"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-prost = "0.9"
+prost = "0.10"
 tonic = { path = "../../tonic" }
 
 [build-dependencies]
diff --git a/tests/wellknown-compiled/Cargo.toml b/tests/wellknown-compiled/Cargo.toml
index c2894b6..0268bd8 100644
--- a/tests/wellknown-compiled/Cargo.toml
+++ b/tests/wellknown-compiled/Cargo.toml
@@ -12,9 +12,9 @@ version = "0.1.0"
 doctest = false
 
 [dependencies]
-prost = "0.9"
+prost = "0.10"
 tonic = {path = "../../tonic"}
 
 [build-dependencies]
-prost-build = "0.9"
+prost-build = "0.10"
 tonic-build = {path = "../../tonic-build"}
diff --git a/tests/wellknown/Cargo.toml b/tests/wellknown/Cargo.toml
index 9fc39f5..73f9349 100644
--- a/tests/wellknown/Cargo.toml
+++ b/tests/wellknown/Cargo.toml
@@ -9,8 +9,8 @@ version = "0.1.0"
 # See more keys and their definitions at https://doc.rust-lang.org/cargo/reference/manifest.html
 
 [dependencies]
-prost = "0.9"
-prost-types = "0.9"
+prost = "0.10"
+prost-types = "0.10"
 tonic = {path = "../../tonic"}
 
 [build-dependencies]
diff --git a/tonic-build/Cargo.toml b/tonic-build/Cargo.toml
index 86602ff..91754a7 100644
--- a/tonic-build/Cargo.toml
+++ b/tonic-build/Cargo.toml
@@ -17,7 +17,7 @@ version = "0.6.2"
 [dependencies]
 prettyplease = {version = "0.1"}
 proc-macro2 = "1.0"
-prost-build = {version = "0.9", optional = true}
+prost-build = {version = "0.10", optional = true}
 quote = "1.0"
 syn = "1.0"
 
diff --git a/tonic-health/Cargo.toml b/tonic-health/Cargo.toml
index 3993f1b..d0dc757 100644
--- a/tonic-health/Cargo.toml
+++ b/tonic-health/Cargo.toml
@@ -21,7 +21,7 @@ transport = ["tonic/transport", "tonic-build/transport"]
 [dependencies]
 async-stream = "0.3"
 bytes = "1.0"
-prost = "0.9"
+prost = "0.10"
 tokio = {version = "1.0", features = ["sync"]}
 tokio-stream = "0.1"
 tonic = {version = "0.6", path = "../tonic", features = ["codegen", "prost"]}
diff --git a/tonic-reflection/Cargo.toml b/tonic-reflection/Cargo.toml
index 719b4ce..cbc965c 100644
--- a/tonic-reflection/Cargo.toml
+++ b/tonic-reflection/Cargo.toml
@@ -18,8 +18,8 @@ version = "0.3.0"
 
 [dependencies]
 bytes = "1.0"
-prost = "0.9"
-prost-types = "0.9"
+prost = "0.10"
+prost-types = "0.10"
 tokio = {version = "1.0", features = ["sync"]}
 tokio-stream = {version = "0.1", features = ["net"]}
 tonic = {version = "0.6", path = "../tonic", features = ["codegen", "prost"]}
diff --git a/tonic-types/Cargo.toml b/tonic-types/Cargo.toml
index d902f69..d6e0141 100644
--- a/tonic-types/Cargo.toml
+++ b/tonic-types/Cargo.toml
@@ -15,8 +15,8 @@ repository = "https://github.com/hyperium/tonic"
 version = "0.4.0"
 
 [dependencies]
-prost = "0.9"
-prost-types = "0.9"
+prost = "0.10"
+prost-types = "0.10"
 
 [build-dependencies]
-prost-build = "0.9"
+prost-build = "0.10"
diff --git a/tonic-web/tests/integration/Cargo.toml b/tonic-web/tests/integration/Cargo.toml
index 47fe98d..f26ecdd 100644
--- a/tonic-web/tests/integration/Cargo.toml
+++ b/tonic-web/tests/integration/Cargo.toml
@@ -10,7 +10,7 @@ license = "MIT"
 base64 = "0.13"
 bytes = "1.0"
 hyper = "0.14"
-prost = "0.9"
+prost = "0.10"
 tokio = { version = "1", features = ["macros", "rt", "net"] }
 tokio-stream = { version = "0.1", features = ["net"] }
 tonic = { path = "../../../tonic" }
diff --git a/tonic/Cargo.toml b/tonic/Cargo.toml
index 2889ec0..514484f 100644
--- a/tonic/Cargo.toml
+++ b/tonic/Cargo.toml
@@ -64,8 +64,8 @@ tower-layer = "0.3"
 tower-service = "0.3"
 
 # prost
-prost-derive = {version = "0.9", optional = true}
-prost1 = {package = "prost", version = "0.9", optional = true}
+prost-derive = {version = "0.10", optional = true}
+prost1 = {package = "prost", version = "0.10", optional = true}
 
 # codegen
 async-trait = {version = "0.1.13", optional = true}